VISDB Viral Integration Site DataBase

VIS ID

TVIS44021446

Fusion event

HTLV-1-APP integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr21

Cytoband

q21.3

Reference genome

Start

End

27458563/26086247 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-106b-5p ; hsa-mir-101-3p ; hsa-mir-520c-3p ; hsa-mir-106a-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-15a-5p ; hsa-mir-130a-3p ; hsa-let-7d-5p ; hsa-let-7a-5p ; hsa-mir-16-5p ; hsa-mir-532-3p ; hsa-mir-500a-5p ; hsa-mir-484 ; hsa-mir-423-3p ; hsa-mir-328-3p ; hsa-mir-222-3p ; hsa-mir-196a-5p ; hsa-mir-1260b ; hsa-mir-3620-3p ; hsa-let-7a-2-3p ; hsa-let-7g-3p ; hsa-mir-6504-3p ; hsa-mir-455-3p ; hsa-mir-298 ; hsa-mir-490-5p ; hsa-mir-545-5p ; hsa-mir-3688-3p ; hsa-mir-3662 ; hsa-mir-15b-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-144-3p ; hsa-mir-4786-5p ; hsa-mir-4698 ; hsa-mir-4495 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-567 ; hsa-mir-944 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6881-3p ; hsa-mir-7111-3p ; hsa-mir-6780a-3p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-1229-5p ; hsa-mir-3606-5p ; hsa-mir-6073 ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-3908 ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-4709-3p ; hsa-mir-5093 ; hsa-mir-5584-5p ; hsa-mir-6502-3p ; hsa-mir-3646 ; hsa-mir-3120-3p ; hsa-mir-551b-5p ; hsa-mir-4484 ; hsa-mir-424-3p ; hsa-mir-548ad-3p ; hsa-mir-3672 ; hsa-mir-4461 ; hsa-mir-6864-3p

Nearest miRNA

hsa-let-7c/Upstream/512203; hsa-mir-3197/Downstream/867714;

Nearest TSS

Nearest CpG islands

None/Target, chr21-CpG: 261/Upstream/350347, chr21-CpG: 127/Downstream/83328

Upstream sequence

AAATATTCTCCTTGAGTAACAGTAATGATGTGCTTGAATCACACATGAGATAATTAATAAAATGTTCACATGATTAAGATGAATCTTACCCTCTGGTTCC

Downstream sequence

AGAGGTACTACCAAAAGCAAAGGGTGAGATGAGAAAGCCAACTTATTCTCAAGGGAAATTATCCACTCCATGGGAAGAAAGTGGCAACAGCAACCTGACA