Basic Information
VIS ID
TVIS44021447
Fusion event
HTLV-1-MAP3K7CL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
30545855/29173534 (Hg38)
End
30545855/29173534 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAP3K7CL
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-let-7c/Upstream/2219491; hsa-mir-3197/Downstream/1201760;
Nearest TSS
ENST00000624081/Upstream/27975; ENST00000548219/Downstream/14261;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/99600, chr21-CpG: 137/Downstream/124889
Upstream sequence
tttcagtacaacctacaatcatctaatgctaacaccagcagtacaaagccttccctttggaaagcTCATCTAGAAAACTATGTATCTGAAGGTCATTTAC
Downstream sequence
CAACTGTTTTTTGCCCTACAGAGGAGGAAGAAATGTAAGGCAAAGGAGAATTCAGTTAGATTTTGTCTAGGTTAGGATTACCTGACCTCCATGATGGAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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