Basic Information
VIS ID
TVIS44021467
Fusion event
HTLV-1-ZBTB21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
43421070/42000961 (Hg38)
End
43421070/42000961 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZBTB21
miRNAs that regulate target gene
hsa-mir-548b-3p ; hsa-mir-186-5p ; hsa-mir-140-3p ; hsa-mir-101-3p ; hsa-mir-93-5p ; hsa-mir-425-5p ; hsa-mir-30e-5p ; hsa-mir-6507-5p ; hsa-mir-3119 ; hsa-mir-510-3p ; hsa-mir-488-3p ; hsa-mir-875-5p ; hsa-mir-4715-5p ; hsa-mir-4282 ; hsa-mir-6875-3p ; hsa-mir-2053 ; hsa-mir-569 ; hsa-mir-4772-5p ; hsa-mir-383-5p ; hsa-mir-6845-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-3919 ; hsa-mir-4756-3p ; hsa-mir-3620-3p ; hsa-mir-6865-3p
Nearest miRNA
hsa-let-7c/Upstream/254120; hsa-mir-5692b/Downstream/949967;
Nearest TSS
ENST00000624081/Upstream/47071; ENST00000412906/Downstream/7096;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/46681, chr21-CpG: 233/Downstream/8209
Upstream sequence
CTGAAAAGTGCCTCAAGATGTCCAAATTCCTGATACACAAGTGCAGAATAACTTTATAGAGTATTTATTTTCCATTCCATTCAGTAGAACAGTAACTAGG
Downstream sequence
TACTTaataacagctaaaatttgggtgtttattctgtcacatacacaaaaataaagaagttatttttatgtattaactcaatatttacatcaaccatagg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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