Basic Information
VIS ID
TVIS44021495
Fusion event
HTLV-1-CABIN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
24542446/24146479 (Hg38)
End
24542446/24146479 (Hg38)
Orient
+
Location type
Intronic
Target gene
CABIN1
miRNAs that regulate target gene
hsa-mir-1226-3p ; hsa-mir-151a-3p ; hsa-mir-320a ; hsa-mir-25-3p ; hsa-mir-16-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-1286/Upstream/1260100; hsa-let-7a-3/Downstream/1309167;
Nearest TSS
ENST00000624155/Upstream/48366; ENST00000495121/Downstream/9359;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/134869, chr22-CpG: 70/Downstream/9535
Nearest cancer related gene
CABIN1(OG, No orient, 0)
Upstream sequence
CTGCAAGCTTTGTGGAACTTCACAGCTTCCGGCTTGCACAGCCCCCGTGTTCAGCCTGGAGCAGGTCTGAAGGCCGCCCTGTCTGGGGAGGGGCAAGCCT
Downstream sequence
GAGAGGCAGCAGGTGGAGAGGGGGTGCTTCCTGCCTGAGAAGCTACAGTGTGTCCTCACCAGTAGGAGAGGTCAGTAGGAGGAAGTACACACAGAGGAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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