Basic Information
VIS ID
TVIS44021518
Fusion event
HTLV-1-PACSIN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43396731/43000725 (Hg38)
End
43396731/43000725 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
PACSIN2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-193b-3p ; hsa-mir-7161-5p ; hsa-mir-8087 ; hsa-mir-548u ; hsa-mir-548g-3p ; hsa-mir-548av-3p ; hsa-mir-3691-5p ; hsa-mir-6124 ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-873-5p ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-4433b-3p
Nearest miRNA
hsa-mir-1281/Upstream/1077428; hsa-let-7a-3/Downstream/2200229;
Nearest TSS
ENST00000624155/Upstream/40826; ENST00000443063/Downstream/1715;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/130448, chr22-CpG: 113/Downstream/13690
Upstream sequence
TAAGGAAGGTGACTTGTCTGAGCTATAAGGGGAGGTGATGAGTCAGCCCCAACCCCCACATCAGCAACTTCAGACTCACATTTGCAAGACTAAGAAGAAA
Downstream sequence
AGAAATAAATCCAAAAGGAAATACAAGAAGCATTAAAGAAAATAACAAAGGATAAAACTGGAATTGATTATATCCTTTCACTCAGTCTTCATAAAAGGAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate