Basic Information
VIS ID
TVIS44021524
Fusion event
HTLV-1-CELSR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
46865212/46469315 (Hg38)
End
46865212/46469315 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
CELSR1
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-let-7a-3/Upstream/355547; hsa-mir-12114/Downstream/1805049;
Nearest TSS
ENST00000624155/Upstream/91691; ENST00000426112/Downstream/64885;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/4983, chr22-CpG: 489/Downstream/64105
Upstream sequence
atattgacctcatcaccttgctcccctgtggtccctaatggcacccagcataaaatacacacccctctgtcctgtggtctgcgtgatctgtccctgtcat
Downstream sequence
cgtgtgaccgctcttcctgccccggggcctttgcgcatctcctggctggagcactgccctccttctcagacactggctacacccctgGGTCCCTCGATGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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