Basic Information
VIS ID
TVIS44021526
Fusion event
HTLV-1-TBC1D22A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
47422467/47026571 (Hg38)
End
47422467/47026571 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
TBC1D22A
miRNAs that regulate target gene
hsa-mir-342-5p ; hsa-mir-484 ; hsa-mir-4633-5p ; hsa-mir-532-5p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-8485
Nearest miRNA
hsa-let-7a-3/Upstream/912803; hsa-mir-12114/Downstream/1247793;
Nearest TSS
ENST00000624155/Upstream/110529; ENST00000434707/Downstream/318998;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/166043, chr22-CpG: 19/Downstream/1747
Upstream sequence
gcttttgcagacaacatgatcatcttttttgaaagtctgatggcatttacaaaaaagctactagaaagaacaagagtttagcaagggttcaggatacagg
Downstream sequence
atctacatacaaaaataaactttatttttgtatattaacagtgagaaatgagaaattgaaattgaatgagcaatacaatttataatagcatgaaaatgtg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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