Basic Information
VIS ID
TVIS44021543
Fusion event
HTLV-1-TSC22D3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
106977138/107733908 (Hg38)
End
106977138/107733908 (Hg38)
Orient
-
Location type
Intronic
Target gene
TSC22D3
miRNAs that regulate target gene
hsa-mir-18a-5p ; hsa-mir-124-3p ; hsa-mir-182-5p ; hsa-mir-335-5p ; hsa-mir-1229-3p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-484 ; hsa-mir-19b-3p ; hsa-mir-124-5p ; hsa-mir-3978 ; hsa-mir-6794-3p ; hsa-mir-4639-3p ; hsa-mir-3613-3p ; hsa-mir-4255 ; hsa-mir-499b-3p ; hsa-mir-4735-3p ; hsa-mir-499a-3p ; hsa-mir-18b-5p ; hsa-mir-4796-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-3924 ; hsa-mir-6802-5p ; hsa-mir-223-5p ; hsa-mir-3691-5p ; hsa-mir-3165 ; hsa-mir-4764-5p ; hsa-mir-676-5p ; hsa-mir-511-3p ; hsa-mir-6865-5p ; hsa-mir-6815-5p
Nearest miRNA
hsa-let-7f-2/Upstream/1094012; hsa-mir-105-1/Downstream/2321421;
Nearest TSS
ENST00000429181/Upstream/11636; ENST00000509000/Downstream/40991;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/17224, chrX-CpG: 70/Downstream/41468
Upstream sequence
TTACTTGCGCTGGGGAAGATGTTTGGGGTGGAGTCTGCTTTGGGGCCCCTGAAATCTTGCCAGATAGACAACTGCCTGCCCCACCTCTAGGTTCGGCAGG
Downstream sequence
CACTGCCCGTCTGCTCTTCCCACCCATTTTTCCCTTCACCTCTCAACCCGGAGAATGGGCTGGGCTATTTCATCTCTAGGACCTGCACATTAGAATGTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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