Basic Information
VIS ID
TVIS44021545
Fusion event
HTLV-1-AMMECR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q23
Reference genome
GRCh37/hg19
Start
109537440/110294212 (Hg38)
End
109537440/110294212 (Hg38)
Orient
-
Location type
Intronic
Target gene
AMMECR1
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-let-7a-5p ; hsa-mir-375 ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-181a-5p ; hsa-mir-192-5p ; hsa-mir-10b-3p ; hsa-mir-92a-3p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p
Nearest miRNA
hsa-let-7f-2/Upstream/211994; hsa-mir-105-1/Downstream/2486506;
Nearest TSS
ENST00000429181/Upstream/149357; ENST00000520821/Downstream/23544;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/290767, chrX-CpG: 83/Downstream/23263
Upstream sequence
AACTAATTTGCTTAAAATAGTACAGTGGATTTGTTTTGAGGGTAAATATTTTTCCAAGCATATTATGGAAAGAAAGTATGCTATCATAACTAGACCAAGC
Downstream sequence
CTCATCCCCGAGGATGTTGCTCTGACTTCACGGAGATGAGATCAGCACTTTTACTATCTATATACTAGCACTGTGTCCTTTCTCCCTTCCTCAATCATGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate