Basic Information
VIS ID
TVIS44021548
Fusion event
HTLV-1-ALG13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q23
Reference genome
GRCh37/hg19
Start
110995656/111752428 (Hg38)
End
110995656/111752428 (Hg38)
Orient
+
Location type
Intronic
Target gene
ALG13
miRNAs that regulate target gene
hsa-let-7e-5p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-526b-5p ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-3607-3p ; hsa-mir-1183 ; hsa-mir-548m
Nearest miRNA
hsa-let-7f-2/Upstream/1670210; hsa-mir-105-1/Downstream/1028290;
Nearest TSS
ENST00000429181/Upstream/7582; ENST00000485371/Downstream/318;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/70381, chrX-CpG: 19/Downstream/329426
Upstream sequence
AGTAGTCATTTACTATAAGGTAAAATTGAGAGTGGTATTAATGTGGCAAGATTACATTGATATCTTAATAATGCTCAAACAGAAAAGCttttttttttct
Downstream sequence
tttttgagatggagtctcgctctgtcacccaggctggagtgcagtggcatgatctcggctcagtgcaacctccatctcccagattcaagtgattctcctg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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