Basic Information
VIS ID
TVIS44021563
Fusion event
HTLV-1-GPC3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
132744701/133610673 (Hg38)
End
132744701/133610673 (Hg38)
Orient
-
Location type
Intronic
Target gene
GPC3
miRNAs that regulate target gene
hsa-mir-219a-5p ; hsa-mir-520c-3p ; hsa-mir-1271-5p
Nearest miRNA
hsa-let-7f-2/Upstream/12239620; hsa-mir-105-1/Downstream/558705;
Nearest TSS
ENST00000429181/Upstream/195183; ENST00000370809/Downstream/143029;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/194417, chrX-CpG: 29/Downstream/373381
Nearest cancer related gene
GPC3(TSG, No orient, 0)
Upstream sequence
TTTTGATATACCAGGTAATATACACACAGTCTTAATATCATGTTCGTTCAACATAATTCTTCTGGATACAGCTATGGTAATTTCCGTCTTTGAAGAAATC
Downstream sequence
AACTTGAATGCCCTAGCTAGATGCAACAGGAGAGGGGATGGCTGGGAAATGGGGCACTTGCCTCTCAGAGGATGGCATCTAGTATGAGAAATGGAGATAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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