Basic Information
VIS ID
TVIS44021566
Fusion event
HTLV-1-ARHGEF6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
135856498/136774339 (Hg38)
End
135856498/136774339 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGEF6
miRNAs that regulate target gene
hsa-mir-30c-5p ; hsa-mir-877-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4306 ; hsa-mir-4644 ; hsa-mir-185-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-1253 ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-5197-3p ; hsa-mir-888-5p ; hsa-mir-371a-5p
Nearest miRNA
hsa-let-7f-2/Upstream/223379; hsa-mir-105-1/Downstream/1893372;
Nearest TSS
ENST00000429181/Upstream/5712; ENST00000478471/Downstream/7749;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/6320, chrX-CpG: 63/Downstream/105604
Upstream sequence
TGTTTCTGTATCATCCAGTATTCTTAGAACTGCAAAGAAGCTAAGTAAACCTTCTGGCAGCTTTAGAATGCAGAAATCATTGGCAACTTCACCATGTTTT
Downstream sequence
TATTTGAAAAAAAAAAATACCATAGTATTggccaggcgtggtggctcatgcctgtaatcccagcattttgggatgccaaggtgggcagatcacttgaggt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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