Basic Information
VIS ID
TVIS44021582
Fusion event
HTLV-1-SH3KBP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.12
Reference genome
GRCh37/hg19
Start
19855463/19837345 (Hg38)
End
19855463/19837345 (Hg38)
Orient
+
Location type
Intronic
Target gene
SH3KBP1
miRNAs that regulate target gene
hsa-mir-1914-5p ; hsa-mir-5692a ; hsa-mir-218-5p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-4775 ; hsa-mir-590-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-335-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-3690-1/Upstream/2411391; hsa-let-7f-2/Downstream/179743;
Nearest TSS
ENST00000429181/Upstream/37594; ENST00000424026/Downstream/50114;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/321702, chrX-CpG: 157/Downstream/49564
Upstream sequence
GCATCAATTCCATGTTACATTGTTTTCCTGATCTATGAAAATCTCTCATACTTGGTAATGAGCAAAGGCAACAGGTAAGAAAGGTGGGTCTTCTCACTGA
Downstream sequence
CAAAGTGCCAATGCAAATTAGCAGCATTAACCAATCCAAAAATTAGTTAACTTATGCAATTCATTTAGACTGGACTTCTCCTCATGACCACCTCAATATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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