Basic Information
VIS ID
TVIS44021593
Fusion event
HTLV-1-CASK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p11.4
Reference genome
GRCh37/hg19
Start
41473956/41614703 (Hg38)
End
41473956/41614703 (Hg38)
Orient
+
Location type
Intronic
Target gene
CASK
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-203a-3p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-3908 ; hsa-mir-4724-5p ; hsa-mir-4519 ; hsa-mir-4274 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-646 ; hsa-mir-503-5p
Nearest miRNA
hsa-mir-1587/Upstream/1777090; hsa-let-7f-2/Downstream/4131454;
Nearest TSS
ENST00000429181/Upstream/24621; ENST00000620846/Downstream/50728;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/139830, chrX-CpG: 143/Downstream/308150
Upstream sequence
ctctgcctcccaggttcaagcgattctcctgcctcagcatcctgagtagcggggattacaggtgcgtgccaacacgcccagctaattttgtatttttagt
Downstream sequence
agagacggggtttcaccatgttggtcaggttggtctcaaactcctaacctcgtgatctgcccgccttggcctcccaaagtgctgggattacaggcgtgag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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