Basic Information
VIS ID
TVIS44021612
Fusion event
HTLV-1-BRWD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
80061554/80806055 (Hg38)
End
80061554/80806055 (Hg38)
Orient
+
Location type
Intronic
Target gene
BRWD3
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-mir-5010-3p ; hsa-mir-548at-5p ; hsa-mir-651-5p ; hsa-mir-548aw ; hsa-mir-4795-3p ; hsa-mir-556-3p ; hsa-mir-223-5p ; hsa-mir-6882-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-509-3p ; hsa-mir-126-5p ; hsa-mir-3159 ; hsa-mir-22-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-377-3p ; hsa-mir-216b-3p ; hsa-mir-4704-5p ; hsa-mir-297 ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-8068
Nearest miRNA
hsa-let-7f-2/Upstream/1904806; hsa-mir-105-1/Downstream/3419697;
Nearest TSS
ENST00000429181/Upstream/71910; ENST00000474113/Downstream/3628;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/231015, chrX-CpG: 21/Downstream/3369
Upstream sequence
CACCTACCCCAAGAAAAAGTATCCCATCTCTTCTACAATGCAGCCACTCAAAATCAGGTCATATGTGAAATAATTTTAATCAAAAATATTACTGACAAAC
Downstream sequence
TTAGCAATCAAACCAACACTGCACATTCACTTCTCAGCCACTACACTTCTGTTCAAATTATCACTCAACCCTGCCCATCTTCTCTTACAAAGAAGTCCAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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