Basic Information
VIS ID
TVIS44021631
Fusion event
HTLV-1-CD24 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrY
Cytoband
q11.222
Reference genome
GRCh37/hg19
Start
21388789/19226903 (Hg38)
End
21388789/19226903 (Hg38)
Orient
-
Location type
Intronic
Target gene
CD24
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-12120/Upstream/5747637;
Nearest TSS
ENST00000430575/Upstream/149487; ENST00000465253/Downstream/467703;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/148784, chrY-CpG: 41/Downstream/275692
Nearest cancer related gene
CD24(OG, No orient, 0)
Upstream sequence
atggagtcttgctcttgttgcccaggctggagtgcaatggtgcgatcttggctcactgcaacctctgcctcccaggtacaagtgattcccctccctcagc
Downstream sequence
ctcctgagtagatgggattacagacacccgccatcacacctagctatttttagtatttttagtagatatggggtttcaccatgttggctactctggtctc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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