Basic Information
VIS ID
TVIS44021644
Fusion event
HTLV-1-GPSM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
109471609/108928987 (Hg38)
End
109471609/108928987 (Hg38)
Orient
-
Location type
Intronic
Target gene
GPSM2
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-5687 ; hsa-mir-32-3p ; hsa-mir-4474-5p ; hsa-mir-4704-3p ; hsa-mir-383-3p ; hsa-mir-3065-3p ; hsa-mir-323a-3p ; hsa-mir-569 ; hsa-mir-378a-5p ; hsa-mir-17-3p ; hsa-mir-4526 ; hsa-mir-3660 ; hsa-mir-103b ; hsa-mir-122-5p ; hsa-mir-143-5p ; hsa-mir-215-3p ; hsa-mir-3135b ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-500b-3p ; hsa-mir-504-3p ; hsa-mir-564 ; hsa-mir-5693 ; hsa-mir-5698 ; hsa-mir-6499-3p ; hsa-mir-6773-3p ; hsa-mir-6854-5p ; hsa-mir-6879-3p ; hsa-mir-7705 ; hsa-mir-891a-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1031683; hsa-mir-11399/Downstream/669906;
Nearest TSS
ENST00000473358/Upstream/14610; ENST00000473828/Downstream/14540;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/51571, chr1-CpG: 68/Downstream/34072
Upstream sequence
ctgaggctgaagaatcacttgaacctgaaagatggaggttgcagtgagccaggatcacaccactgcagtcctgcctggatgacagagcgagaatccgtct
Downstream sequence
caaaaaaaaaaaaaaaaaaaTTCATTCTGGGCTATTTCTTAACAGATTTAACAGCCTAAGAcagaggcaggcaaactttttctgtaaaaggccagataga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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