Basic Information
VIS ID
TVIS44021664
Fusion event
HTLV-1-PLOD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
12026369/11966312 (Hg38)
End
12026369/11966312 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA1A
Target gene
PLOD1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-484 ; hsa-mir-149-5p ; hsa-mir-23b-3p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-12136/Upstream/1998854; hsa-mir-101-1/Downstream/62846;
Nearest TSS
ENST00000473358/Upstream/1610; ENST00000481933/Downstream/5231;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/31400, chr1-CpG: 73/Downstream/13744
Upstream sequence
AATGGTGAGGACCCTAGCCTGCTTCCCACTTCCCACAGGACTGGAAGGAGAAGTACATCCACCAGAACTACACCAAAGCCCTGGCAGGGAAGCTGGTGGA
Downstream sequence
GACGGTAAGGGCCATGGACACCCTCTTGGACCAGCCTTGCCTGCTGCAGGGGGCAGGGCACAGAAGGGAAACTGCTTGCCCTGGGGAGTGGGGGACAGCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate