Basic Information
VIS ID
TVIS44021670
Fusion event
HTLV-1-BCL9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
147051258/147579458 (Hg38)
End
147051258/147579458 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
BCL9
miRNAs that regulate target gene
hsa-mir-101-3p ; hsa-mir-98-5p ; hsa-mir-605-5p ; hsa-mir-92a-3p ; hsa-mir-30c-2-3p ; hsa-mir-30a-5p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1728813; hsa-mir-1182/Downstream/755021;
Nearest TSS
ENST00000473358/Upstream/38046; ENST00000497938/Downstream/20738;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/335830, chr1-CpG: 81/Downstream/19998
Nearest cancer related gene
BCL9(OG, No orient, 0)
Upstream sequence
AAACTTCTCAAATGCAGAGAATTGCCTTTCTCTACTATATGGAATATATACACTGCTTGACACAGATGGTGCTTAATAAATGCTTCCTTAGAAAATGACT
Downstream sequence
GCTGTTCTACCCCTGCTAGCAAGAAGTTAAACCTGAGGGTGCCCCTCTTATAGCCCATGTCCTAAAGGGGCTCTCAGACCCATGCTGGGAAATGCTATCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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