Basic Information
VIS ID
TVIS44021699
Fusion event
HTLV-1-SWT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
185142167/185173035 (Hg38)
End
185142167/185173035 (Hg38)
Orient
-
Location type
Intronic
Target gene
SWT1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-19b-3p
Nearest miRNA
hsa-mir-101-1/Upstream/4734645; hsa-mir-1182/Downstream/7543293;
Nearest TSS
ENST00000473358/Upstream/15553; ENST00000609881/Downstream/127883;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/15462, chr1-CpG: 114/Downstream/143162
Upstream sequence
tgggaggctgaggcaggggaatcgcttgaacctgggaggcggaggttgtggtgagccaagattgcaccactgcagtccagcctggcgacaaagcgagact
Downstream sequence
ccgtctcaaaaaaaaaaaaaaaaaaagaagaaaatggtatgttattgttattattagcatgtctgtgattgctagagaagtcaaactttttaaaaatgtt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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