Basic Information
VIS ID
TVIS44021703
Fusion event
HTLV-1-AKR7L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
19586837/19260343 (Hg38)
End
19586837/19260343 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
AKR7L
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-5698 ; hsa-mir-891a-3p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-103b ; hsa-mir-5693 ; hsa-mir-7705 ; hsa-mir-6854-5p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-3194-3p
Nearest miRNA
hsa-mir-12136/Upstream/363195; hsa-mir-101-1/Downstream/1373336;
Nearest TSS
ENST00000473358/Upstream/2631; ENST00000432465/Downstream/28907;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/8129, chr1-CpG: 72/Downstream/13412
Nearby gene
MRTO4(+215) ;
Upstream sequence
GACACCCTCTCAGTGCCTCTGTTCTTTGGAGACTTCCTACTCCCGCCCACTTCTCACCACGCCCTTGGGAAGGACAGCAGGAAGCAGGCTTCGGGCAGAA
Downstream sequence
GAGGAATTCACCATGTTCACCCAGGCCTAGGCCAGGTCAAGCACCAGCCTCAGCAGGAAGTGCTGAAGGAGAGCTCAGGCCCGGCCCTCTCGCCTTGTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate