Basic Information
VIS ID
TVIS44021707
Fusion event
HTLV-1-ASPM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
197108752/197139622 (Hg38)
End
197108752/197139622 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1K
Target gene
ASPM
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-let-7a-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-101-1/Upstream/557141; hsa-mir-1182/Downstream/1719251;
Nearest TSS
ENST00000473358/Upstream/4478; ENST00000475659/Downstream/7072;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/261334, chr1-CpG: 59/Downstream/6526
Upstream sequence
cttctagctattttgaaatatacaataattactatagtgaccctactgatctattgaacatttggtctttatttcttttatcaaacAGAAAGTTGACACA
Downstream sequence
ATATCCTGTCATTTTAATACACACTTTAACAATTCTTCCAGGCTGTTATTCAACAACAAAAATCAATTCATTTCCATGTGAAATGCAATTAATGCTTCAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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