Basic Information
VIS ID
TVIS44021735
Fusion event
HTLV-1-ITPKB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.12
Reference genome
GRCh37/hg19
Start
226896122/226708421 (Hg38)
End
226896122/226708421 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
ITPKB
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-183-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-3065-5p ; hsa-mir-590-3p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-410-3p ; hsa-mir-133b ; hsa-mir-133a-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-1228-3p ; hsa-mir-6813-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4674 ; hsa-mir-4437 ; hsa-mir-4313 ; hsa-mir-378g ; hsa-mir-939-3p ; hsa-mir-6850-3p ; hsa-mir-4292 ; hsa-mir-6791-5p ; hsa-mir-331-3p ; hsa-mir-873-5p ; hsa-mir-3914 ; hsa-mir-941 ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20b-5p ; hsa-mir-4428 ; hsa-mir-498 ; hsa-mir-561-5p ; hsa-mir-6830-5p
Nearest miRNA
hsa-mir-101-1/Upstream/786279; hsa-mir-1182/Downstream/1233169;
Nearest TSS
ENST00000473358/Upstream/39524; ENST00000521431/Downstream/29037;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4741, chr1-CpG: 171/Downstream/28438
Upstream sequence
TCAAACCTGCCTCAAACCGTTGGTAGAATAACAGCTCAAGGGACCTAACTGAGACCCACCCAAATGTATGCTCTTTGGAGCTACTCCCAGagtcaatact
Downstream sequence
aattgttataagccactcccatgccagaggctgacttaggcacgagtaactcgagacattctggtcaatgagacacaggggatatctgctgggagccttc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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