Basic Information
VIS ID
TVIS44021737
Fusion event
HTLV-1-TSNAX-DISC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.2
Reference genome
GRCh37/hg19
Start
232157906/232022160 (Hg38)
End
232157906/232022160 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA1H
Target gene
TSNAX-DISC1
Nearest miRNA
hsa-mir-101-1/Upstream/1002236; hsa-mir-1537/Downstream/1601992;
Nearest TSS
ENST00000473358/Upstream/203255; ENST00000428673/Downstream/137931;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/394791, chr1-CpG: 173/Downstream/607182
Upstream sequence
tgtcaccttcactatgttccatacattgaaggaatttcaagggccatccaggtttaacaggagaagtaataaactctgttttttgatggtggagaggcaa
Downstream sequence
tattccagaaaagtgtgtTGCTATGACCACACCTACACTCTGCCATACCTGGGCATGGCATGGAAATGGCCAAGGAAGTTTTGCCTAGTCCCTCATTTAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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