Basic Information
VIS ID
TVIS44021753
Fusion event
HTLV-1-EFCAB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
245258465/245095163 (Hg38)
End
245258465/245095163 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1I
Target gene
EFCAB2
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-431-5p ; hsa-mir-3976
Nearest miRNA
hsa-mir-101-1/Upstream/1748908; hsa-mir-3124/Downstream/2106804;
Nearest TSS
ENST00000473358/Upstream/11707; ENST00000479923/Downstream/12016;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/123754, chr1-CpG: 323/Downstream/58082
Upstream sequence
CAGGAGCCAAGGGGGCATCTGAGGGCAAGGAAGCATGGTGCAAGAGGATAGCAAACATCACACAACCGGAACAGCCCGTGCAGGGCCGCTGCTGCAGGGG
Downstream sequence
ATGGCTTTGCACTGGCTCAGGTTCAAGGCCTGCAAGACACAGCCCACTGAGCTGAGCTCCGTCTGGCCTGGGCAGGCAAGGAAGGACCTTGCTTCTAGGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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