Basic Information
VIS ID
TVIS44021757
Fusion event
HTLV-1-CNST integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
246753410/246590108 (Hg38)
End
246753410/246590108 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1I
Target gene
CNST
miRNAs that regulate target gene
hsa-mir-10a-5p ; hsa-mir-150-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3243853; hsa-mir-3124/Downstream/611859;
Nearest TSS
ENST00000473358/Upstream/23594; ENST00000570141/Downstream/92000;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/23134, chr1-CpG: 42/Downstream/29787
Upstream sequence
acattagccctttgtcagatgagtaggttgcaaaaattttctcccattctgtagtttTAATGaactcctcattaaagaaggaagaggctttattcgggcg
Downstream sequence
ggagctttggcagacttgcatcttaagagccaagctccctgaaaaagaaatccttggcccttttaagggcttacaactctaaggggtccacgtgaaaggg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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