Basic Information
VIS ID
TVIS44021761
Fusion event
HTLV-1-TENT5B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
27332693/27006202 (Hg38)
End
27332693/27006202 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA1A
Target gene
TENT5B
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-140-3p ; hsa-mir-4438 ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-638 ; hsa-mir-4713-3p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-4290 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-3692-5p ; hsa-mir-1205 ; hsa-mir-519d-5p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a
Nearest miRNA
hsa-mir-12136/Upstream/451609; hsa-mir-101-1/Downstream/3732954;
Nearest TSS
ENST00000473358/Upstream/11883; ENST00000472249/Downstream/6634;
Nearest CpG islands
chr1-CpG: 36/Target, None/Upstream, None/Downstream
Upstream sequence
CGCCAGTGCGGCAATGAGGTCCAGCGTCTGGCGGCGCTCGTGGTTCATGAGGCACACGGTGCTCTCGTTGACCACCCGGTGCAGTGTCACCAGGCAGGCG
Downstream sequence
TAACGGCGGGCTGCATCTGCCCCACCGAAGTGGGCCTCCAGGTAGCGCTCTAGGGTGCGCCGCTGCTCCACCAGGTCTGGAAAGTCGATGAAGAAGCGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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