Basic Information
VIS ID
TVIS44021762
Fusion event
HTLV-1-AHDC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
27904443/27577932 (Hg38)
End
27904443/27577932 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
AHDC1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-1207-5p ; hsa-mir-1233-5p ; hsa-mir-1273h-5p ; hsa-mir-149-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-28-5p ; hsa-mir-30b-3p ; hsa-mir-3139 ; hsa-mir-3184-5p ; hsa-mir-3612 ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-423-5p ; hsa-mir-4688 ; hsa-mir-4722-5p ; hsa-mir-4728-5p ; hsa-mir-4763-3p ; hsa-mir-486-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6721-5p ; hsa-mir-6743-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6778-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6785-5p ; hsa-mir-6799-5p ; hsa-mir-6805-5p ; hsa-mir-6883-5p ; hsa-mir-708-5p ; hsa-mir-7106-5p
Nearest miRNA
hsa-mir-12136/Upstream/1023339; hsa-mir-101-1/Downstream/3161224;
Nearest TSS
ENST00000473358/Upstream/9672; ENST00000430683/Downstream/25482;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1755, chr1-CpG: 76/Downstream/25139
Upstream sequence
GGGGCCAGTGCTCAGAGGTGATACTGAATACCCTGAGAGGCCAGAGCCCCAACAGAGATTCCACCTGAGGCCAGGGAGTTAAGACTCCAGGGGAGGGAAC
Downstream sequence
CCCTGACTCCCCAGCCCACAGCCCAGATGTTCTCCCAGGCAGTCAGACTACACCCAGTTCAAGTCTGCTAAGGGTGTAACCTCTGGCGAGTACAACCCTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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