Basic Information
VIS ID
TVIS44021764
Fusion event
HTLV-1-MECR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p35.3
Reference genome
GRCh37/hg19
Start
29519347/29192835 (Hg38)
End
29519347/29192835 (Hg38)
Orient
+
Location type
UTR3
Target gene
MECR
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-let-7f-1-3p ; hsa-mir-331-3p
Nearest miRNA
hsa-mir-12136/Upstream/2638242; hsa-mir-101-1/Downstream/1546321;
Nearest TSS
ENST00000473358/Upstream/10848; ENST00000427046/Downstream/7754;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/10661, chr1-CpG: 41/Downstream/37873
Upstream sequence
ataaagctcactcatttgtgagagcccaccttcaaacttcacctcaaggaagcatacccctgtccctggggcctagggcaagatctttattctgctctta
Downstream sequence
cagcaccccacatatcttctttacagcattagtcactatggtaattactgtgagattgtttaatgcacggtttatcaacgacctcatgaacattgaacat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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