Basic Information
VIS ID
TVIS44021780
Fusion event
HTLV-1-MEGF6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.32
Reference genome
GRCh37/hg19
Start
3414339/3497775 (Hg38)
End
3414339/3497775 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MEGF6
Nearest miRNA
hsa-mir-12136/Upstream/369740; hsa-mir-101-1/Downstream/62920;
Nearest TSS
ENST00000473358/Upstream/1058; ENST00000378344/Downstream/33673;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/19148, chr1-CpG: 18/Downstream/2667
Upstream sequence
ATGGAAGGCGAAGGAGCCGGGAGACAGCAGCCGGGGCTCAGCACTGAGGCGACGGGAGCCAGCGACAGCCCTGAGGCCAGCCGAGTGCCCAGGCCCCCCT
Downstream sequence
CAGACAGCAGACCCAAGGCTCCTGACCTGAGCAAGGGACCGCCCAAGTTGTACCCCAAGCAGTGGGGACGGCGCCTCTGCTGGAAGGGGGGCTCGTGTTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate