Basic Information
VIS ID
TVIS44021781
Fusion event
HTLV-1-MEGF6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.32
Reference genome
GRCh37/hg19
Start
3459048/3542484 (Hg38)
End
3459048/3542484 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MEGF6
Nearest miRNA
hsa-mir-12136/Upstream/414449; hsa-mir-101-1/Downstream/18211;
Nearest TSS
ENST00000473358/Upstream/11036; ENST00000378344/Downstream/68793;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/10989, chr1-CpG: 28/Downstream/826
Upstream sequence
CTCCAACCCGGCTGGCAGTGGAGGGAGGAAGCTGGGCTTGCATGGACACCTGCCAGGGGTCCCCAGGCCTGGATGTAGGGTCCTGGCCGCCCCCCACTCA
Downstream sequence
GCCTGATGTGGGATCCTGGTCCCCGAGGACCATGGTCAAGAGGAGGCAGAGGAAGGCAGGTGGAGAGAGTGGGGAGCCCAGGCCGAGGGGAAGATGGGCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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