Basic Information
VIS ID
TVIS44021787
Fusion event
HTLV-1-CTPS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.2
Reference genome
GRCh37/hg19
Start
41449650/40983978 (Hg38)
End
41449650/40983978 (Hg38)
Orient
+
Location type
Intronic
Target gene
CTPS1
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-let-7b-5p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-1260b ; hsa-mir-4737 ; hsa-mir-106a-3p ; hsa-mir-580-3p ; hsa-mir-4703-3p ; hsa-mir-621 ; hsa-mir-381-5p ; hsa-mir-2276-3p ; hsa-mir-4772-3p ; hsa-mir-4742-5p ; hsa-mir-1322 ; hsa-mir-196b-5p ; hsa-mir-196a-5p ; hsa-mir-523-3p ; hsa-let-7i-5p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-98-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7c-5p ; hsa-let-7a-5p ; hsa-let-7g-5p ; hsa-let-7d-5p
Nearest miRNA
hsa-mir-12136/Upstream/226606; hsa-mir-101-1/Downstream/2187674;
Nearest TSS
ENST00000473358/Upstream/817; ENST00000480420/Downstream/4519;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3534, chr1-CpG: 25/Downstream/33768
Upstream sequence
tataggtgtgagccaccatgcccgacTGCCTTTTACTTCTTTGTTGTTATTGAGAACCTGTCAATGGTGTGACATACAGCTGTGGCTGTTACTTCAAAGA
Downstream sequence
TTAATTGCTTAAAACTGGGAGAGATGTTAAAACATACCTCTTAAGTTTTAAAATTCTGCATTCGTACTCCTACTCTCTAGCGTTGAGGTGAAAATATGCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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