Basic Information
VIS ID
TVIS44021824
Fusion event
HTLV-1-AK5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
77996601/77530916 (Hg38)
End
77996601/77530916 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
AK5
Nearest miRNA
hsa-mir-101-1/Upstream/470714; hsa-mir-11399/Downstream/7602878;
Nearest TSS
ENST00000473358/Upstream/113223; ENST00000478255/Downstream/1191;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/248377, chr1-CpG: 94/Downstream/151616
Upstream sequence
CGTGGCCTAACCCCCATTCTGACTTAATCAGAAGAAAACTAAGGTGGGGGTGGAGTCAGAGGGCAGGAGGGCAAACTTCTCCTCCCGCTCCACTTGCTGG
Downstream sequence
AATGACCAAAGCAAAACCATGATCACAGTCCACAATGCTCATGTCCTTGTGCTGGTGGGCTGCCCTCATGCCCTGAGGGGTGCAAGGATGAGTGTGGTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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