Basic Information
VIS ID
TVIS44021830
Fusion event
HTLV-1-ADGRL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
82042073/81576388 (Hg38)
End
82042073/81576388 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
ADGRL2
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-455-3p ; hsa-mir-18a-3p ; hsa-let-7i-5p ; hsa-mir-221-3p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/4516186; hsa-mir-11399/Downstream/3557406;
Nearest TSS
ENST00000473358/Upstream/18686; ENST00000468283/Downstream/49325;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1245187, chr1-CpG: 281/Downstream/223925
Nearby gene
LOC101927434(No orient, 18686)
Upstream sequence
ACTTCTACCACTCCTCTAAACCTCTCAGcttttctgctttcttttcttctttctctctttatttatttttGCTTCCCTCTAAATCATAAATAATAATAGT
Downstream sequence
TCCTACATCATAGCTTTTTAGATTTTAATGACAGCCTCCAAGGACAGGTGCCAGTTAAATGAAACATATAATTAAAACTTGTGCTATTCTAAAATTGGGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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