Basic Information
VIS ID
TVIS44021838
Fusion event
HTLV-1-DIPK1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
93382073/92916516 (Hg38)
End
93382073/92916516 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
DIPK1A
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-98-5p ; hsa-mir-27a-3p ; hsa-mir-101-3p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-545-5p ; hsa-mir-144-3p ; hsa-mir-1273d ; hsa-mir-497-3p
Nearest miRNA
hsa-mir-101-1/Upstream/6558829; hsa-mir-11399/Downstream/930316;
Nearest TSS
ENST00000473358/Upstream/39366; ENST00000474314/Downstream/44984;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/83951, chr1-CpG: 135/Downstream/44439
Upstream sequence
tcagtcttccaagtagctgggattacaggtgcccgcccccatgcccagctaattttcagatgtttagtagagatgtggtttcaccatgttggccaggctg
Downstream sequence
gtctcgaactcctgacctcaggtgatccacctgccttggcctcacaaagtgctgggattacaggcatgagccactgcacccggccAATCCATCTTTTGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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