Basic Information
VIS ID
TVIS44021845
Fusion event
HTLV-1-PLPPR5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
99382284/98916728 (Hg38)
End
99382284/98916728 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1M
Target gene
PLPPR5
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-1/Upstream/870557; hsa-mir-11399/Downstream/1364513;
Nearest TSS
ENST00000473358/Upstream/254505; ENST00000425113/Downstream/87548;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/254573, chr1-CpG: 74/Downstream/87648
Upstream sequence
caaagataggcagcagatcaaatttggtctgtgggctgcagttggctgacTGACCACTGCTCTAAAATACAAAGGATATAATCAAGAATTTTGGCCAACA
Downstream sequence
ATAACAACGATGATTATTCTTCTTACTCTTAGTATTTTAATTATTAGGAAAGAAATTACCTAATCCTCTGTAGAGTTATATTCCAATATTTAATAAGTCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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