Basic Information
VIS ID
TVIS44021855
Fusion event
HTLV-1-MERTK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
112680323/111922746 (Hg38)
End
112680323/111922746 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2B
Target gene
MERTK
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-126-3p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/151612; hsa-mir-10b/Downstream/1660213;
Nearest TSS
ENST00000437798/Upstream/24082; ENST00000473065/Downstream/74624;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/23405, chr2-CpG: 176/Downstream/131486
Nearest cancer related gene
MERTK(OG, No orient, 0)
Upstream sequence
GTGGACTCGATGCCTATCAGCTCCTACTGCTGAGATCCTCTTGTCCTCACAAGAGTTCAAAGAAGTTATAGAGCTTTCCTGAGGCCATACCTTGAGGTGG
Downstream sequence
TGAGGGACTGGGTGGGCCTCAGCCCTCTGACTGCAAAGCTGCTAGCTAACCTCTGAGCAGCACTGCCCACCAGCCCTTCTGCCTTTGCACACTGCATTTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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