Basic Information
VIS ID
TVIS44021864
Fusion event
HTLV-1-LPIN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
11847832/11707706 (Hg38)
End
11847832/11707706 (Hg38)
Orient
-
Location type
Intronic
Target gene
LPIN1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-92a-3p ; hsa-mir-17-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-485-5p ; hsa-mir-432-3p ; hsa-mir-122-5p ; hsa-mir-1289 ; hsa-mir-129-5p ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4802-3p ; hsa-mir-489-3p ; hsa-mir-514a-3p ; hsa-mir-514b-3p ; hsa-mir-6514-5p
Nearest miRNA
hsa-mir-4261/Upstream/167029; hsa-mir-10b/Downstream/59738;
Nearest TSS
ENST00000437798/Upstream/30111; ENST00000464517/Downstream/16516;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/37399, chr2-CpG: 85/Downstream/38417
Upstream sequence
ggagagagcagcgtggctgggactgggtggtggtgcacgcacggggagaagtgctcggggtcccccactggaggtggagctgcaggatttgcttgtgact
Downstream sequence
ggatgtggcttgggaggggagaaagggagtGGCTGGGGCCTGTCCCAACCAAGCGCTGCTGCTTCTGTGAGCACCACAGGTGCTCACCTGCCTGCTGGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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