Basic Information
VIS ID
TVIS44021907
Fusion event
HTLV-1-TANC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
159906967/159050455 (Hg38)
End
159906967/159050455 (Hg38)
Orient
+
Location type
Intronic
Target gene
TANC1
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p
Nearest miRNA
hsa-mir-128-1/Upstream/7682044; hsa-mir-10b/Downstream/136380;
Nearest TSS
ENST00000437798/Upstream/81784; ENST00000464096/Downstream/85744;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/80566, chr2-CpG: 95/Downstream/235641
Upstream sequence
attacaggtgtgagccaccacacccagccTGTGATATAGTTTTAAATTAAACCAGGTTATCAGAACAGCGTTGCAGTTTTGCCATTTAGCTTTAGGCCCC
Downstream sequence
ATGCTGTGTAACAGAGACTTGTTCTTGAATGTCATTTTATCTGGAAATCCAAGGCTTAGGGTGCCAAGGCATGGTTTTAGTGCATGTTTTTCTTGCAAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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