Basic Information
VIS ID
TVIS44021913
Fusion event
HTLV-1-CERS6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
169558723/168702213 (Hg38)
End
169558723/168702213 (Hg38)
Orient
-
Location type
Intronic
Target gene
CERS6
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-6511b-3p ; hsa-mir-7159-3p ; hsa-mir-5088-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-4762-5p ; hsa-mir-425-5p ; hsa-mir-3591-3p ; hsa-mir-21-3p ; hsa-mir-551b-5p ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-128-1/Upstream/119195; hsa-mir-10b/Downstream/6465420;
Nearest TSS
ENST00000437798/Upstream/245964; ENST00000471833/Downstream/84326;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/245101, chr2-CpG: 22/Downstream/187996
Upstream sequence
aagttttcaattcatggttgaatccatgaatgcagaacctatggataatggggggccaacAGtattaattttattaaacctctcttcttgagtatatatt
Downstream sequence
gaaaaagaatattgtgtgtgatgaaattggaaataggtatgcaatggtgtctgtcttaagaaaaatgcagttctttttcttttgaactgaactttttttc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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