Basic Information
VIS ID
TVIS44021918
Fusion event
HTLV-1-DCAF17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
172344248/171487738 (Hg38)
End
172344248/171487738 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
DCAF17
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-6079 ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-671-5p ; hsa-mir-6828-5p ; hsa-mir-4680-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-4694-3p ; hsa-mir-371b-5p ; hsa-mir-376b-3p ; hsa-mir-376a-3p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-6853-3p ; hsa-mir-1206 ; hsa-mir-103b ; hsa-mir-545-5p ; hsa-mir-664a-3p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-6507-5p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-4503 ; hsa-mir-155-3p ; hsa-mir-4477a ; hsa-mir-6792-5p ; hsa-mir-3124-3p ; hsa-mir-126-5p ; hsa-mir-5580-3p
Nearest miRNA
hsa-mir-128-1/Upstream/2904720; hsa-mir-10b/Downstream/3679895;
Nearest TSS
ENST00000437798/Upstream/8082; ENST00000494587/Downstream/34509;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/52952, chr2-CpG: 32/Downstream/29569
Nearby gene
DCAF17(+2686) ;
Upstream sequence
tctcaaactcctgacctcaagtgatccactcaccttggcctcccaaagtgctgggattacaggtgCCTAGCCAAAATCTTCTGCACTTAAAATAGAAAGA
Downstream sequence
GAGAGAGAGACTTACTATgttatgttgcccaggctgttctcagactcctgggctcaagcaattctcccacctcagtctcccgaagtgctgagattacagg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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