Basic Information
VIS ID
TVIS44021921
Fusion event
HTLV-1-MYT1L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
1813017/1809245 (Hg38)
End
1813017/1809245 (Hg38)
Orient
-
Location type
Intronic
Target gene
MYT1L
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-7856-5p ; hsa-mir-4503 ; hsa-mir-6792-5p ; hsa-mir-501-5p
Nearest miRNA
hsa-mir-10b/Downstream/4165417;
Nearest TSS
ENST00000437798/Upstream/13635; ENST00000426976/Downstream/15167;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/10957, chr2-CpG: 27/Downstream/29829
Upstream sequence
GGCTCTCGGGCATCCTGACAAGCTGTGGACAAGACACAGGACGGCCATTAGTCAACTGTCTAATGTCCCAGCCCTGCAGGGAAGTGGTGGTAAGCAAGGC
Downstream sequence
GTAGAATAGCATTATTAGGTTGGTTGCCAGCAAAAGGCTGTCTGAAAATGAGAAAAAGCAAAAAGACCAATGCATACAGTATGACAGTTATGCACACATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate