Basic Information
VIS ID
TVIS44021928
Fusion event
HTLV-1-MYO1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
192112834/191248108 (Hg38)
End
192112834/191248108 (Hg38)
Orient
+
Location type
Intronic
Target gene
MYO1B
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-378a-5p ; hsa-mir-363-3p ; hsa-mir-4703-3p ; hsa-mir-145-3p ; hsa-mir-6780b-3p ; hsa-mir-4698 ; hsa-mir-7852-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-3646 ; hsa-mir-561-3p ; hsa-mir-3662
Nearest miRNA
hsa-mir-10b/Upstream/2114997; hsa-mir-1244-1/Downstream/15535126;
Nearest TSS
ENST00000437798/Upstream/1825; ENST00000420448/Downstream/14891;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1894, chr2-CpG: 88/Downstream/429739
Upstream sequence
GTGAGTGGGTGGTGTTTGGCTAAGAAGGGATCTTCAGCATGTAGCATCCATGTTTTTAGCATTTGTCCTCCTTTGGGTAAGATTGTCTTCTACCTCCCTT
Downstream sequence
CTACTGTTTTCAATAGCTGAACATTTGGATTTTAATTAAATAGCCTAACaataattatagctatcatttagtatgtgttcattacatgccaagaatttta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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