Basic Information
VIS ID
TVIS44021946
Fusion event
HTLV-1-ACSL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
223789937/222925219 (Hg38)
End
223789937/222925219 (Hg38)
Orient
-
Location type
Intronic
Target gene
ACSL3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-340-5p ; hsa-mir-375 ; hsa-mir-221-3p ; hsa-mir-100-5p ; hsa-mir-377-5p ; hsa-mir-6086 ; hsa-mir-655-5p ; hsa-mir-96-3p ; hsa-mir-329-5p ; hsa-mir-551b-5p ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-26a-1-3p
Nearest miRNA
hsa-mir-10b/Upstream/3018654; hsa-mir-1244-1/Downstream/2085242;
Nearest TSS
ENST00000437798/Upstream/665; ENST00000474422/Downstream/5392;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/63514, chr2-CpG: 33/Downstream/127639
Upstream sequence
tgaggtcaggaattcaagaccagcctggccaacgtgacaaaaccacatctctactaaaattacaaaaattagccagagtggtggcatgtgcctgtagtct
Downstream sequence
cagctgttagggaggctgaagcaggagaattgcttgaactccctcgggaggcagaggttgcagtgagccgagatcgtgccactgcactccagcctgggtg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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