Basic Information
VIS ID
TVIS44021948
Fusion event
HTLV-1-DOCK10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q36.2
Reference genome
GRCh37/hg19
Start
225896604/225031887 (Hg38)
End
225896604/225031887 (Hg38)
Orient
-
Location type
Intronic
Target gene
DOCK10
miRNAs that regulate target gene
hsa-mir-142-3p ; hsa-mir-132-3p ; hsa-mir-26b-5p ; hsa-mir-21-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-10b/Upstream/21347; hsa-mir-1244-1/Downstream/1626823;
Nearest TSS
ENST00000437798/Upstream/49460; ENST00000636099/Downstream/10497;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/446116, chr2-CpG: 114/Downstream/10049
Upstream sequence
GCTTACCCTTCTCTTCAGGATAAGAAAGAAGGAAATGGGATTGTATGCTTGCCTCTGAGGCTCGATAAGGTCAGAAGAACCTGACTTGCCCAGCCTTTGC
Downstream sequence
CACCACTGGCTGTCTTTTGCCAGTCTCCATTCCACTAGCCCTGTCCTCAGGATGTGTGAACAGCCATTCCCTTCATTGCATTCTTAAATAACCACGTTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate