Basic Information
VIS ID
TVIS44021953
Fusion event
HTLV-1-PDE6D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q37.1
Reference genome
GRCh37/hg19
Start
232597543/231732833 (Hg38)
End
232597543/231732833 (Hg38)
Orient
-
Location type
UTR3
Target gene
PDE6D
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-mir-218-5p ; hsa-mir-675-3p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-4747-5p ; hsa-mir-5196-5p ; hsa-mir-4533 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-769-5p ; hsa-mir-4646-5p ; hsa-mir-4786-5p ; hsa-mir-204-3p ; hsa-mir-4728-3p ; hsa-mir-8083
Nearest miRNA
hsa-mir-10b/Upstream/19435; hsa-mir-1471/Downstream/159409;
Nearest TSS
ENST00000437798/Upstream/21702; ENST00000479430/Downstream/48430;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/21710, chr2-CpG: 100/Downstream/47770
Upstream sequence
TGGGAGTTTAGTCTGGTCAGCTGGAAGATGGTGGCTTGGGAAAAAGAGCCATCTGGTTACCTACACAGAGCTGGTCCCCTGGTGGCTGCAGGTAGGTTCT
Downstream sequence
GCTGTTGAGGGAATTAGGGGTGTATGTGTCAAAAATCAAACGTGTGGAGGAAAAAAGTAAACAGTTTCCTCCTCCCTCCAAAAAACCCAAATTCTTGAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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