Basic Information
VIS ID
TVIS44021965
Fusion event
HTLV-1-CENPO integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
25045243/24822374 (Hg38)
End
25045243/24822374 (Hg38)
Orient
+
Location type
UTR3
Target gene
CENPO
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-1825 ; hsa-mir-3621 ; hsa-mir-3925-3p ; hsa-mir-6887-3p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-6729-3p ; hsa-mir-196a-3p ; hsa-mir-4787-5p ; hsa-mir-506-5p ; hsa-mir-543 ; hsa-mir-181a-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-149-5p ; hsa-mir-152-5p ; hsa-mir-1908-5p ; hsa-mir-2682-3p ; hsa-mir-3064-5p ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-4484 ; hsa-mir-4505 ; hsa-mir-4731-5p ; hsa-mir-4794 ; hsa-mir-5787 ; hsa-mir-615-5p ; hsa-mir-6504-5p ; hsa-mir-663a ; hsa-mir-664a-5p ; hsa-mir-6781-3p ; hsa-mir-6787-5p ; hsa-mir-6842-3p ; hsa-mir-7155-5p ; hsa-mir-7704
Nearest miRNA
hsa-mir-3125/Upstream/5473869; hsa-mir-10b/Downstream/506266;
Nearest TSS
ENST00000437798/Upstream/1578; ENST00000606114/Downstream/989;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/28616, chr2-CpG: 129/Downstream/97229
Upstream sequence
CACAACCATCTTAGGCCTGAGCTGTGAACAGCAGGGGGTTGTGTGTCTGTTCTGTTTCTCTGCTTGCCGAACTTTCTCAATAAACCCTATTTCTTATTTA
Downstream sequence
TATTTACGTGGTGCTGGTGGTGTGTGTCTGGGACCACTTTGCACAGCAGTTCTTATTTCCCCCATGCTAGGTCTGGGCTGCCAATCTCTTGCCTTGGGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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