Basic Information
VIS ID
TVIS44021966
Fusion event
HTLV-1-ADCY3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
25062950/24840081 (Hg38)
End
25062950/24840081 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADCY3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-1301-3p ; hsa-mir-1296-5p ; hsa-mir-877-5p
Nearest miRNA
hsa-mir-3125/Upstream/5491576; hsa-mir-10b/Downstream/488559;
Nearest TSS
ENST00000437798/Upstream/7896; ENST00000421904/Downstream/522;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/46323, chr2-CpG: 129/Downstream/79522
Upstream sequence
GCACCCCCACACGCATGTCCACCCCAGTCTTGGTCTTCTCCCGCACATACCTGCCAGGTACACACAGAAAGGAGGGTCAGGGTGTGGCCTTCACGAGGCA
Downstream sequence
GCCAGCTGCCCCTGCTCCTGCAGGAGAAATTCATTGTGGGCCTCTTCCCCTCCACAAGAGGGGGCCTGGCAAGGTCCCCACAGCTTGGTGTTGGGTGGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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