Basic Information
VIS ID
TVIS44021967
Fusion event
HTLV-1-DNMT3A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
25507207/25284338 (Hg38)
End
25507207/25284338 (Hg38)
Orient
+
Location type
Intronic
Target gene
DNMT3A
miRNAs that regulate target gene
hsa-mir-143-3p ; hsa-mir-29a-3p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-194-5p ; hsa-mir-369-5p ; hsa-mir-101-3p ; hsa-mir-193b-3p ; hsa-mir-18a-3p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-539-5p ; hsa-mir-7152-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-660-3p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-2116-3p ; hsa-mir-6887-3p ; hsa-mir-4528 ; hsa-mir-6729-3p ; hsa-mir-340-5p ; hsa-mir-29c-5p ; hsa-mir-2276-3p ; hsa-mir-328-5p ; hsa-mir-4708-3p ; hsa-mir-6508-3p ; hsa-mir-6762-5p ; hsa-mir-6845-5p ; hsa-mir-6846-3p ; hsa-mir-6859-3p ; hsa-mir-6885-5p
Nearest miRNA
hsa-mir-3125/Upstream/5935833; hsa-mir-10b/Downstream/44302;
Nearest TSS
ENST00000437798/Upstream/32027; ENST00000352271/Downstream/57547;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/6778, chr2-CpG: 241/Downstream/56102
Nearest cancer related gene
DNMT3A(TSG, No orient, 0)
Upstream sequence
gcatctcagtttccccacctgtcaggtggagatgactggtctagaCCAATGGAGATTTTGTCTTTCTTGTCtttttttttctacttataaaagtcagtca
Downstream sequence
catatatcataaaaaaatcaaactgtagccaggcgtggtggcttacgcctataatcctagcactttgggaggctgaggcaggctccctcacatatcacct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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