Basic Information
VIS ID
TVIS44021975
Fusion event
HTLV-1-PRKD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
37530221/37303078 (Hg38)
End
37530221/37303078 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRKD3
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-9-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-20a-5p ; hsa-mir-6826-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-6069 ; hsa-mir-2276-3p ; hsa-mir-4772-3p ; hsa-mir-4686 ; hsa-mir-5584-5p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-340-5p ; hsa-mir-5196-5p ; hsa-mir-539-5p ; hsa-mir-4747-5p ; hsa-mir-410-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-5680 ; hsa-mir-583 ; hsa-mir-4311 ; hsa-mir-1276 ; hsa-mir-5687 ; hsa-mir-4773 ; hsa-mir-4511 ; hsa-mir-4803 ; hsa-mir-3133 ; hsa-mir-7844-5p
Nearest miRNA
hsa-mir-1301/Upstream/1831592; hsa-mir-10b/Downstream/10074597;
Nearest TSS
ENST00000437798/Upstream/12116; ENST00000433893/Downstream/13310;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/71022, chr2-CpG: 146/Downstream/21129
Upstream sequence
tttaccaatcgaatgttgccttttccaaaactacctacggccggccccacggcccaacccctgtcctgtgcctataaagaccccagactcagccagtaga
Downstream sequence
gagagagaagcagcttgactggagagaggtgacttgacattggagggacagctggacttcagaggatggcctgactatcgggaagagccgctggacctca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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